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PATHOPHYSIOLOGIC MECHANISMS OF OBESITY-ASSOCIATED CARDIOVASCULAR DISEASE: RFA-HL-02-016

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Purpose: The purpose of this RFA is to stimulate novel research approaches to clarify the biological basis of various obesity-related cardiovascular diseases and disorders, including atherosclerosis, thrombosis, hypertension, cardiomyopathies, heart failure, and arrhythmias and/or sudden death. Emphasis will be placed on basic and clinical mechanistic research that reflects expertise in both obesity and cardiovascular sciences. Areas of high interest in association with cardiovascular disorders include: adipose tissue as a proinflammatory and prothrombotic endocrine organ; lipid infiltration (lipotoxicity) in nonadipose tissues and organs; maladaptation of the cardiovascular, endocrine, and neural systems in obesity; and the impact of obesity on the maturation of the cardiovascular system in young animals. Applications may also include the development of …

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