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Purpose: This Request for Applications (RFA) invites investigators to submit research applications for the George M. O'Brien Kidney Research Centers Program. The emphases for this program are fourfold (1) to continue to attract new scientific expertise into the study of the basic mechanisms of kidney diseases and disorders; (2) to encourage multidisciplinary research focused on the causes of these diseases; 3) explore new basic areas that may have clinical research application; and 4) generate *Developmental Research (DR)/Pilot and Feasibility (P&F) studies of two years duration, which are anticipated will lead to new and innovative approaches to study kidney disease, and the eventual submission of competitive investigator-initiated R01 research grant applications. The mounting complexities associated with the …

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