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Purpose: The purpose of this Request for Applications (RFA) is to provide funding to assess novel agents available through the NCI in early clinical, dose finding trials. This initiative's major objective is the timely completion of trials of promising anti-cancer agents and combinations of agents to establish safe and biologically active treatment schedules for patients with cancer and to establish proof of principle for new agents directed at novel molecular targets. Most of these trials will include pharmacokinetic assessment. Many of these trials will include assessment of drug exposure and effect. …
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