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RESPONSE TO THE PRESIDENTIAL VACCINE INITIATIVE - OVERCOMING THE TUBERCULOSIS LATENCY CHALLENGE: AI-01-009

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Purpose: The objective of this Request for Applications (RFA) is to stimulate investigator-initiated research to elucidate the mechanisms underlying persistent, asymptomatic infection (also referred to as “latency”) with Mycobacterium tuberculosis. Of the 1.86 billion persons infected with M. tuberculosis worldwide, 90% harbor the bacterium but do not display symptoms. However, these latent infections may convert to active tuberculosis that renders patients infectious and capable of transmitting M. tuberculosis to others. The rate of conversion from latent to active tuberculosis depends on the immune status of the patients and may be as high as 10% …

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