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New Research Strategies in Osteogenesis Imperfecta: AR-01-001

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Purpose: This initiative is intended to stimulate and support new research projects that have the potential to increase our understanding of skeletal pathology in osteogenesis imperfecta (OI), and to lead to improved therapeutic approaches to the disease. In particular, it is intended that new studies should test the importance of dysregulated bone remodeling in the pathogenesis of OI, with a view to exploiting pharmacological therapies that may ameliorate the consequences of the underlying genetic defects. A second major goal is an improved understanding of osteoprogenitor cell biology that …

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