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Innovative Use of Non-Mammalian Model Organisms to Study Membrane Transport: DK-01-012

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Purpose: Abnormalities in membrane transport processes are associated with many human diseases such as diabetes, cystic fibrosis, renal tubular acidosis, congestive heart failure (hypokalemia), and several intestinal disorders, all of which contribute to a major health care burden for the United States population. Many of these membrane transport processes are well conserved in lower organisms where the genomes are known, which are genetically tractable, and which are easily manipulated at the cellular and molecular levels. Unicellular organisms (bacteria, yeast) have been used as overexpression systems to provide quantities of wild-type or mutated proteins for structure/function studies, or …

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