Table 2

Association between ischemic stroke and matrix metalloproteinase-2 methylation level

CpG position/methylation %Stroke
n=298
Control
n=258
Crude p valueAdjusted p value
Mean±SDMean±SD
Site 11.88±1.022.13±1.110.0050.036
Site 23.75±1.974.24±2.290.0060.052
Site 34.23±1.954.66±2.080.0130.093
Site 43.59±1.843.96±2.100.0280.103
Site 51.92±0.882.25±1.20<0.0010.002
Site 63.43±1.783.86±2.140.0090.098
Site 72.70±1.173.02±1.410.0030.021
Site 84.46±2.234.98±2.380.0090.041
Average of all sites3.24±1.523.64±1.740.0040.036
  • Bold signifies p<0.05. Adjusted p values were adjusted for age, sex, hypertension, diabetes, hypercholesterolemia, and smoking status.

  • CpG, cytosine-guanine sites.