Table 4

Risk of diabetes mellitus and diabetes with complications in statin users in comparison to non-users

VariableNon-usersStatin usersPS-adjusted model*Fully adjusted model†
OR95% CIp valueOR95% CIp value
Diabetes incident cohort: excluded patients who had diabetes at baseline
N=46,810N=7852 
 Diabetes mellitus6185 (13.2)1650 (21.0)1.441.33 to 1.56<0.0011.401.29 to 1.52<0.001
 Diabetes mellitus with complications935 (2.0)290 (3.7)1.521.26 to 2.24<0.0011.471.23 to 1.76<0.001
Diabetes and obesity incident cohort: excluded patients who had diabetes or obesity at baseline
N=41,424N=5793 
 Diabetes mellitus4997 (12.1)1160 (20.0)1.521.39 to 1.67<0.0011.471.34 to 1.62<0.001
 Diabetes mellitus with complications731 (1.8)206 (3.6)1.711.39 to 2.12<0.0011.651.34 to 2.03<0.001
Healthy cohort
N=35,783N=4563 
 Diabetes mellitus4210 (11.8)936 (20.5)1.731.57 to 1.92<0.0011.621.47 to 1.80<0.001
 Diabetes mellitus with complications604 (1.7)155 (3.4)2.011.59 to 2.53<0.0011.831.46 to 2.30<0.001
Non-obese cohort: excluded patients with obesity at baseline or follow-up
N=29,821N=5340 
 Diabetes mellitus3382 (11.3)1550 (29.0)1.371.24 to 1.51<0.0011.371.24 to 1.52<0.001
 Diabetes mellitus with complications770 (2.6)583 (10.9)1.391.18 to 1.65<0.0011.461.24 to 1.72<0.001
Overall cohort: non-users vs high-intensity statin users
N=49,545N=2470 
 Diabetes mellitus8165 (16.5)1119 (45.3)1.291.16 to 1.43<0.0011.291.15 to 1.43<0.001
 Diabetes mellitus with complications1934 (3.9)514 (20.8)1.161.001 to 1.350.051.191.02 to 1.380.03
Statin users only: high-intensity statin users vs moderate-intensity/low-intensity statin users
Moderate-intensity/low-intensityHigh-intensity 
N=8440N=2470 
 Diabetes mellitus3146 (37.3)1119 (45.3)1.101.07 to 1.13<0.0011.191.08 to 1.31<0.001
 Diabetes mellitus with complications1236 (14.6)514 (20.8)1.131.09 to 1.18<0.0011.251.11 to 1.42<0.001
  • *Adjusted for PS.

  • †Adjusted for: PS, medications that are associated with obesity or diabetes, undergoing non-invasive cardiac and revascularization procedures, and number of inpatient admissions and outpatients encounters during follow-up period.

  • PS, propensity score.