Table 3

Risk of diabetes mellitus and diabetes with complications in the propensity score-matched cohort of statin users and non-users

VariableNon-users N=6728Statin users N=6728OR95% CIp value
Unadjusted OR*
 Diabetes mellitus1977 (29.4)2406 (35.8)1.341.24 to 1.44<0.001
 Diabetes mellitus with complications766 (11.4)952 (14.1)1.281.16 to 1.42<0.001
Adjusted OR for medications that are associated with obesity or diabetes during the follow-up period†
 Diabetes mellitus1.351.26 to 1.46<0.001
 Diabetes mellitus with complications1.281.16 to 1.42<0.001
Adjusted OR for medications that are associated with obesity or diabetes and undergoing non-invasive cardiac or revascularization procedures during the follow-up period‡
 Diabetes mellitus1.331.24 to 1.44<0.001
 Diabetes mellitus with complications1.261.14 to 1.40<0.001
Adjusted OR for medications that are associated with obesity or diabetes, undergoing non-invasive cardiac or revascularization procedures, and number of inpatient admissions and outpatients encounters during the follow-up period§
 Diabetes mellitus1.351.25 to 1.45<0.001
 Diabetes mellitus with complications1.311.18 to 1.45<0.001
Unadjusted OR* in sensitivity analysis (redefining follow-up period to start 360 days after the index date)
 Diabetes mellitus1763 (26.2)2281 (33.9)1.451.34 to 1.56<0.001
 Diabetes mellitus with complications667 (9.9)894 (13.3)1.391.25 to 1.55<0.001
  • *Unadjusted OR, since patients were balanced for all baseline characteristics.

  • †Adjusted OR: adjustment for use of medications that are associated with obesity or diabetes (β-blockers, diuretics, systemic corticosteroids, selective serotonin reuptake inhibitors, antipsychotics, hormone replacement therapy, smoking cessation therapy, and cytochrome P450 inhibitors53).

  • ‡Adjusted OR: adjustment for use of medications that are associated with obesity or diabetes as listed above and undergoing an non-invasive cardiac procedures (cardiac stress test, echocardiography, and cardiac catheterization) or invasive revascularization procedures (percutaneous coronary intervention, coronary artery bypass graft surgery, and peripheral arterial revascularization procedures).

  • §Adjusted OR: adjustment for use of medications that are associated with obesity or diabetes as listed above, undergoing non-invasive cardiac or revascularization procedures, and number of inpatient admissions and outpatients encounters during the follow-up period.