|Insulin AUC pmol/L×4 hours||ISR AUC pmol/min×4 hours||ICR (L/min/m2)|
|Weight loss14||↓31%||↓6% NS||↑42%|
All measurements were conducted following graded infusions of intravenous glucose for 4 hours. ICR was calculated by dividing ISR AUC over insulin AUC. Arrows represent direction of change after intervention. All % changes were significant (p<0.05) unless noted as NS.
AUC, area under the curve; ICR, insulin clearance rate; ISR, insulin secretion rate; NS, not significant.