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Original research
Risks of irritable bowel syndrome in children with infantile urinary tract infection: a 13-year nationwide cohort study
  1. Teck-King Tan1,
  2. Miguel Saps2,
  3. Cheng-Li Lin3,4,
  4. Chang-Ching Wei1,5
  1. 1Department of Pediatrics, Children’s Hospital, China Medical University Hospital, Taichung, Taiwan
  2. 2Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Miami Hospital, Miami, Florida, USA
  3. 3Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
  4. 4Department of Public Health, China Medical University, Taichung, Taiwan
  5. 5School of Medicine, China Medical University, Taichung, Taiwan
  1. Correspondence to Dr Chang-Ching Wei, School of Medicine, China Medical University, Taichung 40402, Taiwan; weilonger{at}gmail.com

Abstract

Early life events play a crucial role in the development of irritable bowel syndrome (IBS). Some evidence suggests the phenomenon of cross-organ sensitization between bladder and colon. Whether urinary tract infection (UTI) during infancy is a risk factor of childhood IBS remains to be elucidated. In this retrospective cohort study, we selected 31 788 infants who had UTI between 2000 and 2011 as a UTI cohort and selected 127 152 infants without UTI as a comparison cohort, matched by age, sex and level of urbanization of living area. Incidence density and HRs with CIs of IBS between UTI and non-UTI cohorts were calculated by the end of 2012. The incidence density of IBS during the study period was 1.52-fold higher in the UTI cohort (95% CI 1.38 to 1.67) compared with the non-UTI cohort (2.05 vs 1.32 per 10 000 person-years). The HR of IBS was slightly higher for boys (1.53; 95% CI 1.34 to 1.73) than for girls (1.50; 95% CI 1.29 to 1.73). The HRs for IBS in children with UTI were greater for those with more UTI-related medical visits/per year (>5 visits, HR 61.3; 95% CI 51.8 to 72.6), with longer length of stay of hospitalization (>7 days, HR 1.75; 95% CI 1.36 to 2.24) and with vesicoureteral reflux (VUR) (HR 1.73; 95% CI 1.35 to 2.22) (p<0.0001, the trend test). Infants with UTI had higher risks of childhood IBS and the risks elevated further with recurrent UTI or UTI with concurrent VUR.

  • irritable bowel syndrome
  • infant
  • urinary tract infection

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Footnotes

  • Contributors T-KT drafted the initial manuscript. C-LL carried out the analysis, reviewed and approved the final manuscript as submitted. MS and C-CW conceptualized and designed the study; coordinated and supervised data collection, critically reviewed the manuscript and approved the final manuscript as submitted.

  • Funding This work was supported by grants from the Ministry of Health and Welfare, Taiwan (MOHW107-TDU-B-212-123004), China Medical University Hospital (DMR-107-044), China Medical University Hospital, Academia Sinica Stroke Biosignature Project (BM10701010021), MOST Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005-), Tseng-Lien Lin Foundation, Taichung, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan.

  • Competing interests None declared.

  • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

  • Ethics approval The Institutional Review Board of the China Medical University Hospital (CRREC-103-048).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Presented at This work was in part published as an abstract (‘Increased risks of irritable bowel syndrome in children with urinary tract infection during their first year of life: a nationwide population-based cohort study’) at NASPGHAN 2017 Annual Meeting in Las Vegas, Nevada, USA.

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