Article Text

other Versions

PDF
Review
Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease
  1. Eduardo Solbes,
  2. Richart W Harper
  1. Internal Medicine - Division of Pulmonary and Critical Care Medicine, UC Davis Medical Center, Sacramento, California, USA
  1. Correspondence to Dr Eduardo Solbes, Internal Medicine - Division of Pulmonary and Critical Care Medicine UC Davis Medical Center, Sacramento, California 95817, USA; esolbes{at}ucdavis.edu

Abstract

Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the 20th century, with predominant use in the construction, automotive, and shipbuilding industries. Asbestos has been linked to a spectrum of pulmonary diseases, such as pleural fibrosis and plaques, asbestosis, benign asbestos pleural effusion, small cell lung carcinoma, non-small cell lung carcinoma, and malignant mesothelioma. There are several mechanisms through which asbestos can lead to both benign and malignant disease, and they include alterations at the chromosomal level, activation of oncogenes, loss of tumor suppressor genes, alterations in cellular signal transduction pathways, generation of reactive oxygen and nitrogen species, and direct mechanical damage to cells from asbestos fibers. While known risk factors exist for the development of asbestos-related malignancies, there are currently no effective means to determine which asbestos-exposed patients will develop malignancy and which will not. There are also no established screening strategies to detect asbestos-related malignancies in patients who have a history of asbestos exposure. In this article, we present a case that highlights the different biological responses in human hosts to asbestos exposure.

  • asbestos
  • mesothelioma
  • bronchogenic carcinoma
  • pleural plaques
  • pleural fibrosis

Statistics from Altmetric.com

Footnotes

  • Contributors Both authors conceptualized, wrote, and revised the article. ES is the guarantor of the article and performed literature search.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.