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Wnt signaling and podocyte dysfunction in diabetic nephropathy
  1. Madhura Bose,
  2. Sadia Almas,
  3. Sharma Prabhakar
  1. Division of Nephrology, Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
  1. Correspondence to Dr Sharma Prabhakar, Division of Nephrology, Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 97430, USA; sharma.prabhakar{at}ttuhsc.edu

Abstract

Nephropathy is a major microvascular complication of diabetes mellitus and often leads to terminal renal failure in addition to contributing significantly to cardiovascular morbidity and mortality. Despite continuous advances, the pathogenesis of diabetic nephropathy remains poorly understood. Recent studies have underscored the significance of structural and functional changes in podocytes in the development and progression of diabetic nephropathy. The role of podocytes in health and diabetic nephropathy and abnormalities including podocyte hypertrophy, effacement, and apoptosis, and a detailed discussion on the role played by the Wnt-β-catenin signaling pathway in podocyte injury and dysfunction are the focus of this review. In addition, the role played by Wnt signaling in mediating the effects of known therapeutic strategies for diabetic nephropathy is also discussed.

  • diabetic nephropathies
  • signal transduction
  • physiological processes

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Footnotes

  • Contributors MB contributed significantly to the development of the manuscript. SA has done the literature search and prepared some parts of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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