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Serum and vitreous fibulin-1 concentrations in patients with diabetic retinopathy
  1. Meiling Tian1,
  2. Jing Wang2,
  3. Yuqin Wei3,
  4. Qingle Lu1,
  5. Baohua Huang4
  1. 1Department of Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
  2. 2Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
  3. 3Department of Anesthesiology, The Third People's Hospital of Jinan, Jinan, People's Republic of China
  4. 4Department of Laboratory, Yuhuangding Hospital, Yantai, People's Republic of China
  1. Correspondence to Dr Baohua Huang, Department of Laboratory, Yuhuangding Hospital, 20 Yuhuangding Eastern Road, Yantai, Shandong Province 264000, People's Republic of China; hbaohang{at}163.com

Abstract

Fibulin-1, an extracellular matrix glycoprotein, is closely correlated with angiogenesis. The purpose of this investigation is to determine serum and vitreous fibulin-1 concentrations in diabetic retinopathy (DR). This cross-sectional investigation was carried out in a population of 154 diabetic patients (54 without DR, 42 with non-proliferative diabetic retinopathy (NPDR) and 58 with proliferative diabetic retinopathy (PDR)) and 49 control subjects. The diabetic group showed higher serum and vitreous fibulin-1 concentrations than the controls. Serum and vitreous fibulin-1 concentrations in PDR patients were significantly elevated compared with those in the other 3 groups. NPDR patients showed elevated levels of serum and vitreous fibulin-1 concentrations compared with patients without DR. Logistic regression analysis revealed that serum and vitreous fibulin-1 were risk factors for developing DR. Pearson correlation analysis showed that serum fibulin-1 was correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose and vitreous fibulin-1. Furthermore, Pearson correlation analysis showed that vitreous fibulin-1 was correlated with SBP, DBP, high-density lipoprotein cholesterol and serum fibulin-1. Serum and vitreous fibulin-1 concentrations are elevated under DR condition.

  • Diabetes Mellitus
  • Diabetes Complications

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