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Role of hepatic macrophages in alcoholic liver disease
  1. Cynthia Ju1,
  2. Suthat Liangpunsakul2,3
  1. 1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA
  2. 2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
  3. 3Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA
  1. Correspondence to Dr Suthat Liangpunsakul, Division of Gastroenterology and Hepatology, 550 N. University Blvd, UH 4100, Indianapolis, IN 46202, USA; sliangpu{at}iupui.edu

Abstract

Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD. In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.

  • Liver Diseases, Alcoholic
  • Macrophages

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