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Original research
Impact of weight loss on inflammation and red blood cell biomarkers after laparoscopic gastric banding surgery
  1. Susana Coimbra1,2,
  2. Cátia Ferreira3,
  3. Luís Belo1,3,
  4. Petronila Rocha-Pereira1,4,
  5. Alice Catarino5,
  6. Luís Monteiro5,
  7. Cristina Catarino1,3,
  8. Alice Santos-Silva5
  1. 1 UCIBIO, REQUIMTE, Porto, Portugal
  2. 2 CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra-Paredes, Portugal
  3. 3 Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia da Universidade do Porto (FFUP), Porto, Portugal
  4. 4 Centro de Investigação em Ciências Saúde (CICS), Universidade da Beira Interior, Covilhã, Portugal
  5. 5 Hospital da Prelada-Dr. Domingos Braga da Cruz, Porto, Portugal
  1. Correspondence to Professor Susana Coimbra, UCIBIO \ REQUIMTE, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; ssn.coimbra{at}gmail.com and Professor Alice Santos-Silva, Hospital da Prelada-Dr. Domingos Braga da Cruz, Rua de Sarmento de Beires 153, 4250-449 Porto, Portugal; assilva{at}ff.up.pt

Abstract

Adipose tissue produces several adipokines that are enrolled in different metabolic and inflammatory pathways that may disturb iron metabolism and erythropoiesis. Considering that laparoscopic adjustable gastric banding (LAGB) has not been associated with a long-term risk of malabsorption, we performed a 13-month follow-up study in severe obese patients submitted to LAGB in order to clarify its impact on inflammation, iron metabolism and on red blood cell (RBC) biomarkers. Twenty obese patients were enrolled in the study, being clinical and analytically assessed before (T0) and 13 months after LAGB intervention (T1). Inflammation, iron bioavailability and RBC biomarkers were evaluated at T0 and T1. At T1, weight and anthropometric indices decreased significantly; patients showed a significant increase in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (MCHC), and a reduction in red cell distribution width, ferritin, hepcidin, tumor necrosis factor-α, interleukin-6 (IL-6) and C-reactive protein. Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.

  • obesity
  • inflammation
  • iron metabolism disorders
  • hematology
  • laparoscopy

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Footnotes

  • Contributors Conception or design of the work: SC, CC and AS-S. Data collection: SC, CF, PR-P, AC, LM and CC. Data analysis and interpretation: SC, CF, LB, LM, CC and AS-S. Critical revision of the article: SC, LB, CC and AS-S. Final approval of the version to be published: all authors.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The study protocol was approved by the Committee on Ethics of Hospital da Prelada-Dr Domingos Braga da Cruz.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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