Article Text

PDF
Effects of curcumin in experimental diabetic nephropathy
  1. Sharma S Prabhakar
  1. Correspondence to Dr Sharma S Prabhakar, Texas Tech University Health Sciences Center, Room 4B071 3601 4th Street STOP 9410, Lubbock, TX 79430-6271, USA; sharma.prabhakar{at}ttuhsc.edu

Abstract

Diabetic nephropathy (DN) is currently well established as the most common cause of end-stage renal disease in most parts of the world. Notwithstanding the expanding basic and clinical research in this field, the pathogenesis remains far from clear and hence the treatment of DN remains suboptimal. There is a critical need for the development of newer therapeutic strategies including alternative and complementary therapies. One of the natural products that was extensively studied in cancer and other chronic disease states such as diabetes is curcumin, an active ingredient in turmeric, a spice extensively used in India. In this manuscript, we present a critical review of the experimental and clinical evidence that supports the use of curcumin and its analogs in DN as well as the various proposed mechanisms for its biological actions in health and disease states.

  • Diabetic Nephropathies
  • Drugs, Investigational

Statistics from Altmetric.com

Footnotes

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.