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13 The effects of bio sugar influence on toad sciatic nerve-trunk action potential
  1. Chengzhe Jiang1,
  2. Mingxun Cui1,
  3. Honglong Li1,
  4. Taiyuan Li1,
  5. Xiwen Liu2
  1. 1Agriculture College of Yanbian University, Yanji, China
  2. 2Affiliated Hospital of Yanbian University, Yanji, China

Abstract

Objectives MSD is a type of bio sugar made by an MS bio sugar research institute in South Korea. The bio sugar has a glycan structure with a functional group on the monosaccharide. Our objective was to observe the effects of different concentrations of MSD on toad sciatic nerve-trunk action potential, and whether MSD can improve the inhibitory effect on toad sciatic nerve-trunk action potential of hypertonic glucose solution.

Methods Toad sciatic nerve trunks were randomly divided into three groups, namely a control group, an MSD group and a hypertonic glucose group. Following soaking with different concentrations of MSD, toad sciatic nerve-trunk action potential amplitudes and conduction velocities were determined using a BL-420 biological function experimental system.

Results Compared with the control group, 1% MS inhibited toad sciatic nerve-trunk action potential amplitude and conduction velocity but the effects disappeared after 10 min, while 0.5% MSD decreased action potential amplitude and increased conduction velocity. Soaking in 10% hypertonic glucose with 0.5% MSD after processing permanently inhibited toad sciatic nerve-trunk action potential. MSD can inhibit toad sciatic nerve-trunk action potential amplitude and conduction velocity.

Conclusions The activity of 0.5% MSD is better than that of 1% MSD. MSD can improve the inhibitory effects of 10% hypertonic glucose solution on toad sciatic nerve-trunk action potential.

Acknowledgments This research was financially supported by the National Natural Science Foundation of China (Grant No. 31260207).

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