Modulators of ICR and plasma insulin concentration. Insulin resistance increases insulin secretion rate and decreases insulin clearance rate to raise plasma insulin concentration. Weight gain and treatment with salsalate decrease insulin clearance whereas weight loss and treatment with thiazolidinediones increase insulin clearance. Plus (+) sign denotes stimulatory effects and negative (−) sign, inhibitory effects.
Changes (%) in plasma insulin, ISR and ICR during graded infusions of intravenous glucose
Insulin AUC pmol/L×4 hours
ISR AUC pmol/min×4 hours
All measurements were conducted following graded infusions of intravenous glucose for 4 hours. ICR was calculated by dividing ISR AUC over insulin AUC. Arrows represent direction of change after intervention. All % changes were significant (p<0.05) unless noted as NS.
AUC, area under the curve; ICR, insulin clearance rate; ISR, insulin secretion rate; NS, not significant.
Kim, S. H., & Reaven, G. M.(2016).
Insulin clearance: an underappreciated modulator of plasma insulin concentration.
Journal of Investigative Medicine,64(7),
Accessed April 23, 2017.https://doi.org/10.1136/jim-2016-000149.