Article Text

PDF
Soluble Klotho and fibroblast growth factor 23 levels in diabetic nephropathy with different stages of albuminuria
  1. Ayca Inci1,
  2. Funda Sari2,
  3. Melahat Coban3,
  4. Refik Olmaz1,
  5. Suleyman Dolu1,
  6. Metin Sarıkaya1,
  7. Necat Yılmaz4
  1. 1Antalya Training and Research Hospital, Antalya, Turkey
  2. 2Department of Nephrology, Akdeniz University Faculty of Medicine, Antalya, Turkey
  3. 3Antalya Egitim ve Arastirma Hastanesi, Antalya, Turkey
  4. 4Department of Biochemistry, Antalya Training and Research Hospital, Antalya, Turkey
  1. Correspondence to Dr Ayca Inci, Antalya Training and Research Hospital, Antalya 07100, Turkey; aycainci2004{at}hotmail.com

Abstract

The relationship between soluble Klotho (s-Klotho) levels, fibroblast growth factor 23 (FGF23) levels, and albuminuria in patients with diabetic chronic kidney disease (CKD) remains unclear. A total of 109 patients with type 2 diabetes (mean age 61.63±9.77 years), at the outpatient clinic of the Antalya Research and Training Hospital Nephrology Unit between January and June 2014, as well as 32 healthy controls (mean age 49.53±7.32 years) were enrolled for this cross-sectional study. Patients were classified into three groups according to their urinary albumin creatinine ratio (UACR), normoalbuminuria (UACR<30 mg/g), microalbuminuria (UACR 30–300 mg/g), and macroalbuminuria (UACR>300 mg/g). The blood was analyzed for FGF23, s-Klotho, parathyroid hormone (PTH), P, Ca, creatinine, and 25-hydroxyvitamin D3 (25hD) levels. Creatinine, s-Klotho, FGF23, and PTH levels were significantly higher and 25hD levels were significantly lower in the patient group than in the healthy controls (p<0.001). Between the groups according to UACR, 1-way analysis of variance revealed statistically significant differences for creatinine (p<0.001), 25hD (p<0.001), PTH (p=0.002), Ca (p=0.002), and albumin levels (p<0.001). A statistically significant positive correlation was found between s-Klotho and FGF23 (r=0.768; p=0.001), and between FGF23 levels and UACR (r=0.768; p=0.001). In conclusion, the results of the present study suggest that s-Klotho levels are significantly elevated in patients with diabetes and s-Klotho levels decreased with increasing albumin excretion in our patients despite a reduction in estimated glomerular filtration rate.

  • Diabetic Nephropathies
  • Proteinuria
  • Kidney Failure, Chronic

Statistics from Altmetric.com

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.