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Serum Sclerostin Levels in Newborns Born to Mothers With Vitamin D Deficiency
  1. Gonca Sandal, MD*,
  2. Ozgur Pirgon, MD,
  3. Bumin Dundar, MD,
  4. Hasan Cetin, MD*,
  5. Halil Ibrahim Bayram, MD§
  1. From the *Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Süleyman Demirel University; †Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Süleyman Demirel University, Isparta; ‡Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Katip Celebi University, Izmir; §Department of Biochemistry, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
  1. Received September 5, 2014, and in revised form February 10, 2015.
  2. Accepted for publication March 30, 2015.
  3. Reprints: Ozgur Pirgon, MD, Department of Pediatrics, Division of Pediatric Endocrinology, Faculty of Medicine, Süleyman Demirel University, 32260, Cunur, Isparta, Turkey. E-mail: ozgurpirgon{at}gmail.com.
  4. The authors have no conflicts of interest to disclose.

Abstract

Aim Sclerostin inhibits osteoblast functions, differentiations, and survival rates. The aim of this study was to investigate the association between circulating sclerostin (an emerging biomarker and important regulator of bone formation) and neonatal parameters in mothers with vitamin D deficiency.

Method Forty-five mothers and their newborns were recruited in the study. The mothers were divided into 2 groups as vitamin D–deficient group 25(OH)D (25-hydroxyvitamin D3 < 20 ng/mL) and vitamin D–sufficient group 25(OH)D (>20 ng/mL). Their newborns had measurements of weight, height, calcium, phosphate, alkaline phosphatase, sclerostin, and 25(OH)D at birth.

Results The mothers with vitamin D deficiency had significantly lower vitamin D levels than the mothers with vitamin D sufficiency (8.7 [3.4] ng/mL vs 26.7 [4.0] ng/mL, P < 0.001). There were no significant differences between women with vitamin D deficiency and women with vitamin D sufficiency for sclerostin concentrations (205.4 [64.8] pg/mL vs 291.6 [122.9] pg/mL). However, 25(OH)D (10.1 [8.1] ng/mL vs 33.4 [11.6] ng/mL, P < 0.001) and sclerostin concentrations (182.9 [15.3] pg/mL vs 288.8 [32.3] pg/mL, P = 0.01) were lower in newborns born by mothers with vitamin D deficiency compared and with newborns of mothers with vitamin D sufficiency. Circulating sclerostin measurements were not associated with 25(OH)D levels of both mothers and their newborns.

Conclusions We found significantly lower sclerostin levels in newborns born by women with vitamin D deficiency compared with newborns of nondeficient mothers.

Key Words
  • sclerostin
  • vitamin D
  • newborn
  • mother

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