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The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated With Susceptibility of Alzheimer Disease in Chinese Population
  1. Yun-Kang Yang, MD*,
  2. Xiao-Dong Peng, PhD,
  3. Yong-Hong Li, PhD‡§,
  4. Zheng-Rong Wang, MD*,
  5. Huang Chang-quan, MD,
  6. Wang Hui, MD,
  7. Qing-Xiu Liu, MD
  1. From the *Key Laboratory of Chronobiology of Health Ministry, Basic and Forensic School, Sichuan University, Chengdu; †Department of Oncology, The Affiliated Hospital of North Sichuan Medical College, Nanchong; and ‡Key Laboratory of Biological Effect of Physical Field and Instrument of Sichuan Provincial Department of Education and §Department of Electronic Engineering, Chengdu University of Information Technology, Chengdu, Sichuan; and ∥Department of Geriatrics, The Third Hospital of Mian Yang, Mian Yang, China.
  1. Xiao-Dong Peng is co–first author.
  2. This work was supported by the Science and Technology Graveness Project of Sichuan Province (2010FZ0061) and the Illustrious Youth Specialist Project of Sichuan Province (2012JQ005).
  3. The authors extend their full confidence that there are no conflicts of interest in this research article and that only the fullest integrity was practiced in its composition.
  4. Received November 15, 2012, and in revised form March 7, 2013.
  5. Accepted for publication March 16, 2013.
  6. Reprints: Huang Chang-quan, MD, Key Laboratory of Chronobiology of Health Ministry, Basic and Forensic School, Sichuan University, Chengdu; Sichuan, China. E-mail: huangshan319{at}


Objectives In the present study, it was examined whether polymorphism of circadian locomotor output cycle kaput (CLOCK) gene 3111T/C was associated with susceptibility of Alzheimer disease (AD).

Methods This study was conducted using a case-control method. Genotypes of apolipoprotein E (APOE e4) and CLOCK gene 3111T/C were determined by restriction fragment length polymorphism method and TaqMan assay method, respectively.

Results In this study, we gathered 296 unrelated AD patients and 423 control subjects. Both in the whole sample and APOE e4 noncarriers, prevalence of C carriers in CLOCK gene 3111T/C in AD patients was significantly higher than that in control subjects (in the whole sample: χ2 = 37.615, P < 0.0001; in APOE e4 noncarriers: χ2 = 46.809, P < 0.0001). However, among APOE e4 carriers, prevalence of C carriers in CLOCK gene 3111T/C between patients and control subjects presents nonsignificant difference (χ2 = 0.812, P = 0.451).

Conclusions Among APOE e4 noncarriers, C carriers in CLOCK gene 3111T/C were associated with a high susceptibility of AD, but among APOE e4 carriers, the functional polymorphism of CLOCK gene 3111T/C was not associated with the susceptibility of AD.

Key Words
  • CLOCK gene 3111T/C
  • polymorphism
  • Alzheimer disease

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