Article Text

Cystatin C Levels in Patients With Dipper and Nondipper Hypertension
  1. Serkan Ordu, MD*,
  2. Hakan Ozhan, MD*,
  3. Recai Alemdar, MD*,
  4. Hayriye Yildirim, MD,
  5. Adem Gungor, MD,
  6. Sabri Onur Caglar, MD*,
  7. Mesut Aydin, MD*,
  8. Serkan Bulur, MD*
  1. From the Departments of *Cardiology, †Biochemistry, and ‡Internal Medicine, Medicine Faculty, Duzce University, Duzce, Turkey.
  1. Received May 6, 2011, and in revised form September 12, 2011.
  2. Accepted for publication January 4, 2012.
  3. Reprints: Serkan Bulur, MD, Duzce Universitesi Düzce Tıp Fakültesi 81620, Konuralp, Düzce, Turkey. E-mail: drserkanbulur{at}
  4. The authors have no conflicts of interest.


Objective Subjects with nondipper hypertension carry a higher risk of cardiovascular events than their normotensive counterparts. The present study was designed to investigate cystatin C levels in patients with dipper and nondipper hypertension.

Methods Eighty-eight consecutive patients who had been treated with antihypertensive drugs for at least 6 months were included in the study. Dipping and nondipping patterns were detected with ambulatory blood pressure monitoring. Clinical, laboratory, and ambulatory blood pressure monitoring data of patient groups with nondipper and dipper hypertension were compared.

Results Patients in the nondipper group were older than those in the dipper group. Serum cystatin C level was higher in the patients in the nondipper group. Cystatin C was negatively correlated with the rate of systolic blood pressure fall at night (r = −0.41; P < 0.001). Linear regression analyses revealed that only cystatin C level was a significant correlate of nocturnal systolic blood pressure decrease. Logistic regression analyses also showed that cystatin C was an independent predictor of nondipping pattern (odds ratio, 3.586; 95% confidence interval, 1.432–8.98; P = 0.006]).

Conclusion The present study showed that cystatin C is higher in patients with nondipper hypertension patients.

Key Words
  • cystatin C
  • hypertension
  • dipping

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