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Levels of Blood Periostin Decrease After Acute Myocardial Infarction and Are Negatively Associated With Ventricular Function After 3 Months
  1. Chi-Wen Cheng, MD,
  2. Chao-Hung Wang, MD,
  3. Ju-Fang Lee, Msc,
  4. Li-Tang Kuo, MD,
  5. Wen-Jin Cherng, MD
  1. From the Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung; Chang Gung University College of Medicine, Taoyuan, Taiwan.
  1. Received December 10, 2010, and in revised form September 9, 2011.
  2. Accepted for publication November 4, 2011.
  3. Reprints: Chao-Hung Wang, MD, Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, 222 Mai Chin Rd, Keelung, Taiwan. E-mail: bearty54{at}; bearty{at}
  4. This study was supported by Heart Failure Center Research Program, Chang Gung Memorial Hospital, Keelung (grant numbers: CMRPG280221, 280251, and 280261), and Healthy Aging Research Program, Chang Gung University (grant number EMRPD1A0841).


Background A recent study showed that periostin (PN) induced reentry of differentiated cardiomyocytes into the cell cycle and improved heart function after acute myocardial infarction (AMI). This study sought to investigate whether PN levels increase after AMI and whether they provide prognostic value.

Methods and Results We recruited 123 patients: 45 with AMI, 45 with stable coronary artery disease (CAD), and 33 healthy controls (CON). Blood PN and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels were measured. Echocardiography was repeated 3 months after AMI. In the AMI group, the PN levels 1.3 ± 1.2 days after AMI were significantly lower than those in the CAD and CON groups (175 ± 60, 245 ± 68, and 232 ± 63 ng/mL, respectively, P = 0.001). The NT-pro-BNP levels were significantly higher in the AMI group, compared to the CON and CAD groups (10.07 ± 28.2 [median, 0.70] vs 0.08 ± 0.06 [median, 0.05] and 1.1 ± 4.2 [median, 0.09] ng/mL, respectively; P = 0.02). The PN levels further decreased 8 ± 2 days after AMI (from 175 ± 60 to 143 ± 57 ng/mL; P = 0.003). However, NT-pro-BNP levels did not significantly change. With respect to the echocardiographic parameters 3 months after AMI, the PN levels measured before discharge were negatively associated with the left ventricular ejection fraction (r s = −0.50; P = 0.001), end diastolic (r s = 0.42; P = 0.009) and systolic (r s = 0.46; P = 0.004) diameters. The NT-pro-BNP levels were not significantly correlated with these parameters.

Conclusion Acute myocardial infarction is associated with a decrease in blood PN levels, and PN concentrations predict cardiac function 3 months after AMI.

Key Words
  • periostin
  • acute myocardial infarction
  • outcome
  • brain natriuretic peptide

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