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Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms
  1. Wassef Karrowni, MD*,
  2. Saadeddine Dughman, MD*,
  3. Georges P. Hajj, MD*,
  4. Francis J. Miller Jr, MD*†
  1. From the *Department of Internal Medicine, The University of Iowa; and †Department of Medicine, Veterans Affair Medical Center, Iowa City, IA.
  1. Received March 28, 2011, and in revised form August 24, 2011.
  2. Accepted for publication August 24, 2011.
  3. Reprints: Francis J. Miller, Jr, MD, Department of Internal Medicine, 285 Newton Rd, Room 2269, Carver Biomedical Research Building, Iowa City, IA 52242. E-mail: francis-miller{at}uiowa.edu.
  4. This material is based on work supported in part by the Office of Research and Development, Department of Veterans Affairs (F.J.M.).
  5. The authors have no conflicts of interest to declare.

Abstract

Background The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs).

Methods We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.

Results Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, −1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0–4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.

Conclusions To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.

Key Words
  • statins
  • atherosclerosis
  • abdominal aortic aneurysm

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