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APOA4 Polymorphism as a Risk Factor for Unfavorable Lipid Serum Profile and Depression
  1. Vanessa Kiyomi Ota, Bsc*,
  2. Elizabeth Suchi Chen, PhD*,
  3. Tatiana Flank Ejchel, PhD*,
  4. Tatiane Katsue Furuya, Bsc*,
  5. Diego Robles Mazzotti, Bsc*,
  6. Maysa Seabra Cendoroglo, PhD,
  7. Luiz Roberto Ramos, PhD,
  8. Lara Quirino Araujo, MD,
  9. Rommel Rodriguez Burbano, PhD*,
  10. Marília de Arruda Cardoso Smith, PhD*
  1. From the *Disciplina de Genética, Departamento de Morfologia e Genética, and †Disciplina de Geriatria, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
  1. Received March 11, 2011, and in revised form May 9, 2011.
  2. Accepted for publication May 11, 2011.
  3. Reprints: Vanessa Kiyomi Ota, Disciplina de Genética, Universidade Federal de Sáo Paulo, Rua Botucatu, 740 - Edifício Leitão da Cunha - 1° andar, CEP 04023-900 - São Paulo/SP - Brazil. E-mail: anessakaota{at}gmail.com and Marília de Arruda Cardoso Smith, PhD, Disciplina de Genética, Universidade Federal de São Paulo, Rua Botucatu, 740 - Edifício Leitão da Cunha - 1° andar, CEP 04023-900 - São Paulo/SP - Brazil. E-mail: macsmith.morf{at}epm.br.
  4. This research was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brazil), Coordenadoria de Aperfeiçoamento de Pessoal de Ensino Superior (Brazil), and Fundação de Amparo à Pesquisa do Estado de São Paulo (Brazil).

A Cross-Sectional Study

Abstract

Introduction APOA1/C3/A4/A5 gene cluster is closely involved in lipid metabolism, and its polymorphisms have been associated with coronary heart disease and lipid plasma levels. Here, we aimed to investigate associations of APOC3 (3238C>G, −482C>T, 1100C>T) and APOA4 (Gln360His, Thr347Ser) polymorphisms in 382 individuals from a cohort of a Longitudinal Brazilian Elderly Study with major age-related morbidities and with lipid and protein serum levels.

Materials and Methods The whole sample was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Descriptive statistics, logistic regression analysis, Student t test, deviation from Hardy-Weinberg, Bonferroni correction for multiple testing, and haplotype analyses were performed.

Results Although APOC3 1100T allele carriers presented lower triglyceride and very low density lipoprotein levels than non-T carriers, these associations disappeared after Bonferroni correction (P > 0.05). Moreover, APOA4 360His allele was associated with depression (P = 0.03), increased triglyceride (P = 0.035) and very low density lipoprotein (P = 0.035) levels, and reduced HDL levels (P = 0.0005). Haplotype analyses found an association between His/C/C haplotype (Gln360His/−482C>T/1100C>T) with depression, but this result was due to Gln360His polymorphism.

Conclusions Our data suggest that 360His allele might be a risk factor for depression and unfavorable lipid profile and depression for elderly people in the Brazilian population.

Key Words
  • APOC-III
  • APOA-IV
  • elderly population
  • HDL
  • triglycerides

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