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Elevated Plasma Levels of Chemerin in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension
  1. Mengliu Yang, MD*†,
  2. Gangyi Yang, PhD,
  3. Jing Dong, MD,
  4. Ying Liu, MD,
  5. Haihong Zong, MD,
  6. Hua Liu, PhD§,
  7. Guenther Boden, MD,
  8. Ling Li, MS*
  1. From the *Department of Clinical Biochemistry and the Key Laboratory of Laboratory Medical Diagnostics in Ministry of Education, Chongqing Medical University, Chongqing, China; †Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China; ‡Department of Medicine/Endocrinology, Albert Einstein College of Medicine, Bronx, NY; §Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS; and ∥The Division of Endocrinology/Diabetes/Metabolism and The Clinical Research Center, Temple University School of Medicine, Philadelphia, PA.
  1. Received February 20, 2010, and in revised form May 2, 2010.
  2. Accepted for publication June 9, 2010.
  3. Reprints: Ling Li, MS, Department of Clinical Biochemistry, Chongqing Medical University, Chongqing, 400016, China. E-mail: lingli31{at}yahoo.com.cn.
  4. Supported by research grants from the National Natural Science Foundation of China (30871199, 30771037, and 30971388), Chongqing Medical University (XBZD200704), and the National Institutes of Health (R01-DK 58895 to G.B.).
  5. Mengliu Yang and Gangyi Yang contributed equally to this project.

Abstract

Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome.

Key Words
  • chemerin
  • type 2 diabetes mellitus
  • hypertension
  • body composition
  • metabolic parameters

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