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Using a Type 1 Collagen-Based System to Understand Cell-Scaffold Interactions and to Deliver Chimeric Collagen-Binding Growth Factors for Vascular Tissue Engineering
  1. Yonggang Pang, MD, PhD*†‡,
  2. Howard P. Greisler, MD*†§
  1. From the *Department of Surgery, Loyola University Medical Center, Maywood; †Edward Hines Jr VA Hospital, Hines; ‡Department of Biomedical Engineering, Illinois Institute of Technology, Chicago; and §Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Maywood, IL.
  1. Received May 4, 2010.
  2. Accepted for publication June 22, 2010.
  3. Reprints: Howard P. Greisler, MD, Department of Surgery, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153. E-mail: hgreisl{at}lumc.edu.
  4. Supported by grants from the NIH R01-HL41272 (HPG), Department of Veteran's Affairs (HPG), and Chicago Association for Research and Education in Science (HPG). This symposium was supported in part by a grant from the National Center for Research Resources (R13 RR023236).

Abstract

Vascular tissue engineering should provide more biocompatible and functional conduits than synthetic vascular grafts. Understanding cell-scaffold interactions and developing an efficient delivery system for growth factors and other biomolecules to control the signaling between the cells and the scaffold are fundamental issues in a wide range of tissue engineering research fields. Type 1 collagen is a natural scaffold extensively used in vascular tissue engineering and is a widely used vehicle in biomolecule delivery. In this article, we will discuss type 1 collagen as a vascular tissue engineering scaffold, describe strategies for elucidating the interaction between cells and type 1 collagen scaffolds using various imaging techniques, and summarize our work on the development of a chimeric collagen-binding growth factor-based local delivery system.

Key Words
  • type 1 collagen
  • growth factor
  • confocal microscopy
  • local delivery
  • scaffold

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