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Left Ventricular Diastolic Function in Patients on Hemodialysis
  1. Veena Raizada, MD*,
  2. Betty Skipper, PhD,
  3. Robert A. Taylor, MD*,
  4. Wentao Luo, MS*,
  5. Antonia A. Harford, MD*,
  6. Philip G. Zager, MD, PhD*,
  7. Mark Rohrscheib, MD*,
  8. Charles T. Spalding, MD, PhD*
  1. From the Departments of *Internal Medicine and †Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM.
  1. Received December 30, 2009, and in revised form April 27, 2010.
  2. Accepted for publication May 5, 2010.
  3. Reprints: Veena Raizada, MD, MSC 10-5550, 1 University of New Mexico, Albuquerque, NM 87131-0001. E-mail: vraizada{at}salud.unm.edu.
  4. Supported, in part, by the National Institutes of Health's National Center for Research Resources' General Clinical Research Center grant no. 5M01 RR00997 (University of New Mexico Health Science Center, Albuquerque, NM).

Abstract

Background Previous studies have shown that the assessment of Doppler mitral flow velocity (DMFV) curves can be used to predict prognosis owing to left ventricular (LV) diastolic dysfunction in certain specific diseases. Our aim was to study whether the prognostic value of DMFV curves is affected by the many end-stage renal disease factors, such as chronic uremia and long-term hemodialysis (HD), which cause LV diastolic dysfunction and death.

Methods Retrospective echo Doppler studies obtained 10 to 12 hours after HD in 90 patients (52 males; mean age, 56 years) were analyzed to determine changes in deceleration time (DT) of the early mitral filling wave (E) and the ratio of E to the atrial velocity (A). The study findings (n = 83) showed 2 groups of DT: long DT (DT > 240 milliseconds) and normal/short DT (DT ≤ 240 milliseconds). Continuous variables of LV size using internal dimensions, systolic function using ejection fraction, hypertrophy using wall thickness and mass, and pulmonary hypertension and E/A were compared between the 2 groups.

Results Patients with long DT versus normal/short DT had lower absolute and indexed LV mass (P = 0.03 and P = 0.02, respectively) and pulmonary hypertension (P ≤ 0.001), without a significant difference in LV systolic function or E/A. The mortality rate, adjusted for age and sex, was lower with long DT versus normal/short DT, with a hazard ratio of death, 0.44 (95% confidence interval, 0.23-0.86, P = 0.02).

Conclusions Our study identified characteristics of DMFV curves in patients on long-term HD, which are clearly of value in predicting outcomes and survival in these patients.

Key Words
  • dialysis
  • ESRD
  • ventricle
  • diastole
  • mitral

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