Article Text

Randomized Clinical Trials in Stroke Research
  1. Chul Ahn, PhD*,
  2. Daniel Ahn, DO
  1. From the Departments of *Clinical Sciences, and †Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX.
  1. Received August 31, 2009.
  2. Accepted for publication November 6, 2009.
  3. This research was partially supported by the National Institutes of Health grant UL1 RR024982. The presentation of the paper was made at the Epi Summer Workshop 2009 held at Busan, Korea.
  4. Reprints: Chul Ahn, PhD, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9066. E-mail: chul.ahn{at}


A randomized clinical trial is widely regarded as the most rigorous study design to determine the efficacy of intervention because spurious causality and bias associated with other experimental designs can be avoided. The purpose of this article is to provide clinicians and clinical researchers the types of randomized clinical trials used in stroke studies and to discuss the advantages and the limitations for each type of randomized stroke clinical trials.

Key Words
  • RCT
  • advantages
  • disadvantages

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