Article Text

Glucocorticoid Efficacy in Asthma
  1. Robert J. Freishtat, MD, MPH*†‡,
  2. Kanneboyina Nagaraju, DVM, PhD†‡,
  3. William Jusko, PhD§,
  4. Eric P. Hoffman, PhD†‡
  1. From the *Division of Emergency Medicine, and †Research Center for Genetic Medicine, Children's National Medical Center; ‡School of Medicine and Health Sciences, The George Washington University, NW, Washington, DC; and §Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY.
  1. Received June 15, 2009, and in revised form July 07, 2009.
  2. Accepted for publication July 07, 2009.
  3. Reprints: Robert J. Freishtat, MD, MPH, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010. E-mail: rfreishtat{at}
  4. Supported by the National Institutes of Health, Bethesda, MD, via grant K23-RR-020069 to R.J.F. and by institutional funding from Children's National Medical Center. This symposium summarized in this manuscript was supported in part by a grant from the National Center for Research Resources (R13 RR023236).

Is Improved Tissue Remodeling Upstream of Anti-Inflammation


Synthetic glucocorticoids (GCs), such as prednisone, are among the most widely prescribed drugs worldwide and are used to treat many acute and chronic inflammatory conditions. The current paradigm of GC efficacy is that they are potent anti-inflammatory agents. Decreased inflammation in many disorders is thought to lead to decreased pathological tissue remodeling. However, this model has never been validated. In particular, improvements in inflammation have not been shown to improve the rate of lung function decline in asthma. Herein, we present an alternative paradigm, where GC efficacy is mediated through more successful tissue remodeling, with reduction in inflammation secondary to successful regeneration.

Key Words
  • glucocorticoid
  • asthma
  • tissue remodeling
  • lung
  • inflammation

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.