Article Text

Renal Complications in Oncohematologic Patients
  1. Michele Buemi, MD*,
  2. Maria Rosaria Fazio, MD*,
  3. Davide Bolignano, MD*,
  4. Giuseppe Coppolino, MD*,
  5. Valentina Donato, MD*,
  6. Antonio Lacquaniti, MD*,
  7. Stefania Mondello, MD*,
  8. Antoine Buemi, MD*,
  9. Alessandro Allegra, MD
  1. From the *Department of Internal Medicine, and †Division of Hematology, University of Messina, Messina, Italy.
  1. Received April 3, 2009, and in revised form July 13, 2009.
  2. Accepted for publication October 7, 2009.
  3. Reprints: Michele Buemi, MD, Via Salita Villa Contino 30, 98100 Messina, Italy. E-mail: buemim{at}


The aim of the present paper was to review recent developments in the management of patients with acute kidney injury or chronic kidney disease occurring secondary to either cancer itself or its therapy, with a focus on infiltration of the renal parenchyma, myeloma, tumor lysis syndrome, glomerular disease, thrombotic microangiopathy, chemotherapy-associated thrombotic microangiopathy, biphosphonate-induced renal diseases, acute kidney injury, and chronic kidney disease after hematopoietic cell transplantation. Further studies are awaited because a better knowledge of renal complications, which frequently occur in patients with oncohematologic diseases, would be conducive to making an early diagnosis and providing prompt therapy.

Key Words
  • renal failure
  • myeloma
  • thrombotic microangiopathy
  • hemolytic-uremic syndrome
  • hematopoietic cell transplant

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