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Components of Participating Organizations

National Institute of Diabetes and Digestive and Kidney Diseases

National Cancer Institute

National Eye Institute

National Human Genome Research Institute

National Heart, Lung, and Blood Institute

National Institute on Aging

National Institute on Alcohol Abuse and Alcoholism

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Biomedical Imaging and Engineering

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute on Deafness and Other Communication Disorders

National Institute of Dental and Craniofacial Research

National Institute of Environmental Health Sciences

National Institute of General Medical Sciences

National Institute of Mental Health

National Institute of Neurological Disorders and Stroke

National Institute of Nursing Research

National Institute of Standards and Technology

Application Receipt Date(s): November 25, 2008

Earliest Anticipated Start Date(s): July 1, 2009

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) ( on behalf of the NIH Genes, Environment and Health Initiative, solicits Exploratory/Developmental Clinical Research Grant (R21) applications from institutions/ organizations that propose a) clinical studies using information from genome wide association or other genetic studies in common diseases; b) development and assessment of diagnostic, clinical trial, epidemiologic and risk analytic tools for use in clinical research or practice; and c) cost-effectiveness studies of clinical applications of genetic information. Areas of interest include, but are not limited to: development of diagnostic or other risk factor algorithms that incorporate genetic data; pilot interventional studies using findings from genetic studies of common diseases or outcomes related to genetic testing for variants identified in common diseases; pilot research on clinical modification of environmental factors known to interact with specific genes variants identified in common diseases; and cost effectiveness studies. The proposed research must focus on using findings from genetic studies of common diseases with …

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