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Insertion/Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene in Patients with Breast Cancer and Effects on Prognostic Factors
  1. Arzu Yaren,
  2. Sebahat Turgut,
  3. Raziye Kursunluoglu,
  4. Ilhan Oztop,
  5. Gunfer Turgut,
  6. Serkan Degirmencioglu,
  7. Canan Kelten,
  8. Ergun Erdem
  1. From the Department of Internal Medicine (A.Y., S.D.), Division of Medical Oncology, Faculty of Medicine, University of Pamukkale, Denizli, Turkey; Department of Physiology (S.T., R.K., G.T.), Faculty of Medicine, University of Pamukkale, Denizli, Turkey; Institute of Oncology (I.O.), University of Dokuz Eylul, Izmir, Turkey; Department of Pathology (C.K.), Faculty of Medicine, University of Pamukkale, Denizli, Turkey; Department of General Surgery (E.E.), Faculty of Medicine, University of Pamukkale, Denizli, Turkey.
  1. Address correspondence to: Dr. Arzu Yaren, Bursa Cad. No:117 Hur Konut Sitesi 3. Blok D:7, 20070 Kinikli/Denizli, Turkey; e-mail: arzu_yaren{at}; arzuyaren03{at}


The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DD, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p = .03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DD genotype may accompany poor prognostic factors and influence the tumor course.

Key words
  • angiotensin-converting enzyyme gene polymorphism
  • breast cancer
  • prognostic factors

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