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Variability in Postheparin Hepatic Lipase Activity Is Associated with Plasma Adiponectin Levels in African Americans
  1. Jacob J. Clarenbach,
  2. Gloria Lena Vega,
  3. Beverley Adams-Huet,
  4. Robert V. Considine,
  5. Madia Ricks,
  6. Anne E. Sumner
  1. From the Center for Human Nutrition (J.J.C., G.L.V., B.A.-H.), Donald W. Reynolds Cardiovascular Clinical Research Center of the University of Texas Southwestern Medical Center and Metabolic Unit, Veterans Affairs Medical Center, Dallas, TX; Division of Endocrinology and Metabolism (R.V.C.), Indiana University School of Medicine, Indianapolis, IN; and Clinical Endocrinology Branch (A.E.S., M.R.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
  1. This study was supported by intramural funding from the National Institute of Diabetes and Digestive and Kidney Diseases, Veterans Affairs Merit grant, and the Donald W. Reynolds Foundation (Dallas), and the American Diabetes Association (Indiana). Beverley Adams-Huet is supported by University of Texas Southwestern at Dallas General Clinical Research Center grant number MO1-RR0633.
  2. Address correspondence to: Dr. Anne E. Sumner, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 10-CRC, Rm 6-5940, MSC 1612, 9000 Rockville Pike, Bethesda, MD 20892-1612; reprints e-mail: AnneS{at} and Gloria.Vega{at}


Background African Americans commonly have normal high-density lipoprotein cholesterol (HDL-C) and low triglyceride levels despite having insulin resistance and obesity. The higher than expected HDL-C levels are usually attributed to low levels of hepatic triglyceride lipase (HTGL) activity. Factors that regulate HTGL in African Americans are not well delineated.

Methods In the current study, HTGL activity was examined in relation to indices of body fat (body mass index [BMI] and waist circumference [WC]), insulin resistance (fasting plasma insulin and homeostasis model assessment of insulin resistance [HOMA-IR] index), and adipokines (adiponectin and leptin). Sixty-three African Americans (33 men, 30 women; median age 31 years, range 20-50 years; median BMI 28.6 kg/m2, range 19.7-54.7 kg/m2) had anthropometry and measurement of postheparin lipase activities (HTGL), plasma HDL-C, triglycerides, and plasma adiponectin.

Results HTGL correlated strongly with HDL-C (r = −.52, p < .0001) and adiponectin (r = −.49, p < .001). HTGL increased with BMI and WC (r = .297, p = .018 and r = .301, p = .016, respectively). Adiponectin correlated strongly with HDL-C (r = .50, p < .0001) and triglycerides (r = −.493, p < .001). From multiple regression models, 28% of HTGL variability among African Americans can be explained by adiponectin levels in combination with gender and 35% of HTGL is explained with HDL-C included in the model.

Conclusion The data suggest that adiponectin is a significant metabolic concomitant of HTGL activity in African Americans.

Key words
  • adiponectin
  • African Americans
  • hepatic triglyceride lipase

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