Insulin-like growth factor 1 (IGF-1) is recognized as an insulin sensitizer, whereas IGFBP3 acts as an insulin antagonist (Muzumdar RH, Diabetes). Since overnight glucose regulation may be modulated by alterations in the availability of IGF-1 and/or IGFBP3, we hypothesized that oral ethanol ingestion prior to sleep would alter the relationship between IGF-1 and IGFBP3 during sleep. Eleven healthy subjects (age = 63 ± 5 years, HbA1C = 5.0 ± 0.2%, BMI = 27 ± 5 kg/m2) were admitted to the UNM GCRC for two separate 24-hour studies. At 2200, subjects ingested sugar free punch with or without 95% ethanol (ethanol vs placebo) to achieve blood alcohol concentrations of 0.12 ± 0.02% (mild intoxication) by midnight during the ethanol arm of the study. During sleep, glucose, insulin, GH, IGF-1, and IGFBP3 were sampled at baseline and every 30 minutes between midnight and 0800. Results are shown below:
These results demonstrate that IGF-1 availability relative to IGFBP3 is reduced following low-dose ethanol ingestion prior to sleep. This occurs independently of GH concentrations and may reflect a suppressive effect of insulin on IGF-1. This may represent an additional glucose counterregulatory response to reduced glucose concentrations following ethanol ingestion.
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