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115 EFFECT OF ETHANOL BEFORE SLEEP ON OVERNIGHT INSULIN-LIKE GROWTH FACTOR 1 AND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 DYNAMICS IN HEALTHY, NONDIABETIC SUBJECTS.
  1. T. Hammer1,
  2. L. Gamache1,
  3. C. A. Vella1,
  4. M. R. Burge1
  1. 1University of New Mexico Health Sciences Center, Albuquerque, NM.

Abstract

Insulin-like growth factor 1 (IGF-1) is recognized as an insulin sensitizer, whereas IGFBP3 acts as an insulin antagonist (Muzumdar RH, Diabetes). Since overnight glucose regulation may be modulated by alterations in the availability of IGF-1 and/or IGFBP3, we hypothesized that oral ethanol ingestion prior to sleep would alter the relationship between IGF-1 and IGFBP3 during sleep. Eleven healthy subjects (age = 63 ± 5 years, HbA1C = 5.0 ± 0.2%, BMI = 27 ± 5 kg/m2) were admitted to the UNM GCRC for two separate 24-hour studies. At 2200, subjects ingested sugar free punch with or without 95% ethanol (ethanol vs placebo) to achieve blood alcohol concentrations of 0.12 ± 0.02% (mild intoxication) by midnight during the ethanol arm of the study. During sleep, glucose, insulin, GH, IGF-1, and IGFBP3 were sampled at baseline and every 30 minutes between midnight and 0800. Results are shown below:

These results demonstrate that IGF-1 availability relative to IGFBP3 is reduced following low-dose ethanol ingestion prior to sleep. This occurs independently of GH concentrations and may reflect a suppressive effect of insulin on IGF-1. This may represent an additional glucose counterregulatory response to reduced glucose concentrations following ethanol ingestion.

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