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285 EPIDEMIOLOGY OF VALVULAR REGURGITATION IN THE MIDDLE-AGED AFRICAN AMERICAN COHORT OF THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY: AN EVALUATION OF PREVALENCE AND BOTH CLINICAL AND ECHOCARDIOGRAPHIC CORRELATES.
  1. R. S. Wilson1,
  2. A. Penman1,
  3. T. Mosley1,
  4. J. J. King1,
  5. J. G. Towery1,
  6. K. Butler1,
  7. M. R. McMullan1,
  8. H. A. Taylor1,
  9. E. R. Fox1
  1. 1University of Mississippi Medical Center, Jackson, MS

Abstract

Background There are limited data on the prevalence and the clinical and echocardiographic correlates of valvular regurgitation in African Americans despite the higher rates of cardiovascular disease in this group.

Purpose The Jackson, Mississippi, site of the Atherosclerosis Risk in Communities study provides a unique opportunity to study mitral, tricuspid, and aortic regurgitation (MR, TR, and AR) in this population.

Methods There were 2,285 participants who were available for analysis. The prevalence rates of MR, TR, and AR by severity were calculated for participants 50 to 59, 60 to 69, and 70+ years. Multivariable regression analyses were conducted to determine clinical and echocardiographic variables associated with the presence of MR, TR, and AR.

Results Mild or greater MR and TR were present in 14.7% and 17.2% of participants, respectively. AR was present in 15.6% of participants. In the multivariable regression model, MR was independently associated with age, sex, lower body mass index (BMI), systolic blood pressure (SBP), left atrial (LA) size, left ventricular diastolic diameter (LVDD), and low LV ejection fraction (LVEF). TR was independently associated with age, sex, lower BMI, HDL, LA size, and lower relative wall thickness. AR was independently associated with age, sex, lower BMI, SBP, LVDD, LV hypertrophy, and low LVEF.

Conclusion In this middle-aged African American cohort, the prevalence of mild to greater MR and TR was similar to that seen in other cohorts; however, AR was more prevalent. Several cardiovascular risk factors and echocardiographic parameters were identified as independent correlates of valvular regurgitation.

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