Oxidative stress and inflammation are highly prevalent in chronic kidney disease (CKD) and may explain the increased atherosclerotic burden in this population. Obesity is independently associated with increasing oxidative stress and inflammation in the general population. The purpose of this study is to investigate whether obesity, as assessed by body mass index (BMI), can predict oxidative stress and inflammation in patients with CKD. A cross-sectional observational study was conducted on 200 stage II through IV CKD patients. Demographics, cardiovascular disease history, markers of oxidative stress (free F2-isoprostanes, a marker of lipid peroxidation, measured by GC/MS) and inflammation (C-reactive protein [CRP]), and BMI were measured in all patients. Using Spearman rank correlations, BMI was significantly correlated with F2-isoprostanes (r = .271, p < .001) and CRP (r = .214, p = .003). After controlling for age, gender, race, diabetes, smoking history, estimated GFR, serum total cholesterol, and serum albumin in a multivariate linear regression model, BMI remained significantly associated with F2-isoprostanes (beta = 0.008; 95% CI 0.003-0.012; p = .001) and CRP (beta = 0.012; 95% CI 0.003-0.021; p = .01). Obese patients with stage II through IV CKD may be at higher risk of early cardiovascular morbidity and mortality because of increased systemic oxidative stress and inflammatory burden compared with nonobese CKD patients.
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