Background The Glagov hypothesis suggests that positive remodeling preserves lumen size until further plaque formation results in significant narrowing. However, there are no data relating the percent stenosis (%S) to the plaque type and its relationship to patient's gender.
Methods Fifty patients undergoing 64-detector computed tomographic angiography (CTA) were evaluated using the AHA 18 segment model. Stenoses were assigned to quartiles: 0 to 25%, 25 to 50%, 50 to 75%, and > 75%. Plaque was characterized as totally noncalcified (TNC), predominantly nonC (PNC), predominantly C (PC), and totally C (TC).
Results There was a significant (p < .01) direct relationship between the extent of noncalcified plaque and the %S. The association was statistically significant for women but not for men (p < .01 and p = .2, respectively; Table).
Conclusions (1) There is a significant association between vessel lumen and calcification in females but not in males. (2) Noncalcified plaque is directly, and calcified plaque inversely, related to the severity of arterial narrowing; this suggests that positive remodeling associated with predominantly calcified plaque preserves lumen size.
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