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505 AMINOLEVULINIC ACID-BASED PHOTODYNAMIC THERAPY IN CUTANEOUS ONCOLOGY AND COSMETIC DERMASURGERY.
  1. J. Ahdout1,
  2. D. J. Kouba1,
  3. E. Fincher1,
  4. R. L. Moy1
  1. 1David Geffen School of Medicine at UCLA, Los Angeles, CA.

Abstract

Photodynamic therapy (PDT) involves the use of topically applied aminolevulinic acid (ALA), in conjunction with a light sensitizer, to generate reactive oxygen species in the skin. Currently, the only FDA-approved indication for ALA-based PDT is for the treatment of actinic keratoses. However, through a review of the medical literature, it has been found that dermatologists and dermasurgeons alike have, through off-label uses, expanded the possibilities for treatment of a variety of conditions, which include cutaneous oncology and cosmetic dermasurgery. These off-label uses of ALA-PDT include photorejuvination and the treatment of Barrett's esophagus, Paget's disease, acne vulgaris, psoriasis, sebaceous gland hyperplasia, rosacea, and hirsutism.

TABLE 1

Medical Applications of ALA-PDT

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