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388 OXIDATIVE STRESS IN OVERWEIGHT CHILDREN AND ADOLESCENTS.
  1. W. N. Evans1,
  2. G. A. Mayman1,
  3. R. J. Acherman1,
  4. K. A. Cass1,
  5. C. F. Luna1,
  6. A. J.C. Collazos1,
  7. H. Restrepo1
  1. 1Children's Heart Center and University of Nevada, School of Medicine, Las Vegas, NV.

Abstract

Background In adult studies, elevated concentrations of oxidative stress markers have been associated with obesity and other risk factors for cardiovascular disease.

Objective To compare concentrations of urinary oxidative stress markers between overweight and normal-weight children and adolescents.

Methods and Patients This pilot study compared data from 23 children and adolescents with a body mass index (BMI) ≥ 95th percentile, in good health conditions except for their obesity, with a group of 17 normal BMI percentile peers. Oxidative stress test, which includes 8-epi-PGF2£ and 8-epi-PGF2£/creatinine ratio, were measured in a spot urine morning sample. Spearman correlation and nonparametric tests were used for statistical analysis.

Results The group of overweight children was composed of 14 boys and 9 females, with a mean age of 12.3 ± 2.0 years and a mean BMI Z-score of 2.1 ± 0.4; the group of normal-weight children had 12 boys and 5 girls, with a mean age of 13.7 ± 2.2 and a mean BMI Z-score of −0.5 ± 1.3. There was no significant difference between groups in 8-epi-PG F2£ (2,561.8 ± 1,578.2 vs 2,601.5 ± 1,337.2 pg/mL, p = .7) or 8-epi-PGF2£/creatinine ratio (17.2 ± 5.2 vs 17.9 ± 5.9, p = .8). 8-epi-PG F2£ was not correlated with BMI or BMI Z-score.

Conclusion In this group of overweight children and adolescents, oxidative stress markers were not significantly elevated or correlated with BMI.

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