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Introduction to Pathologic Calcification
  1. Virginia M. Miller,
  2. John C. Lieske,
  3. Abdulla K. Salahudeen
  1. From the Departments of Surgery and Physiology and Biomedical Engineering (V.M.M.), Division of Nephrology and Hypertension (J.C.L.), Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, and the University of Texas M. D. Anderson Cancer Center (A.K.S), Houston, TX.
  1. A symposium presented at Experimental Biology '06, sponsored by The American Federation for Medical Research in collaboration with the American Physiological Society.
  2. Address correspondence to: Dr. Virginia M. Miller, Department of Surgery, Medical Science 4-62, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905; e-mail: miller.virginia{at}mayo.edu.

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One of the American Federation for Medical Research (AFMR) missions is to facilitate translational research. With that objective, AFMR is proud to continue to sponsor the bench to bed side symposia at the annual Experimental Biology (EB) meeting. More details on how to apply to hold a symposium at a future EB meeting is provided at <www.AFMR.org>.

The symposium Pathological Calcification: Crystallization, Infection, or Cellular Transdifferentiation, sponsored by the American Federation for Medical Research, was held at the 2006 Experimental Biology Meeting in San Francisco, CA, April 1-5, 2006.

The pathophysiology of calcification within human tissues is complex. Although inflammation appears to be a common characteristic associated with many calcific processes, including advanced atherosclerosis, nephrolithiasis, and calciphylaxis of end-stage renal disease, it is unclear if these associated cellular responses promote or ameliorate the calcification. Experimental evidence supports several theories regarding the pathogenesis of these pathogenic biomineralizations, including the transdifferentiation of vascular smooth muscle cells to …

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