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14 INCREASING QUARTILES OF OBESITY ARE ASSOCIATED WITH A MORE ATHEROGENIC PROFILE.
  1. M. Barchie,
  2. K. Colleran
  1. University of New Mexico, Albuquerque, NM

Abstract

Introduction Adipocytokines affect numerous atherogenic processes including endothelial function, coagulation, and inflammation. Obese individuals have a proatherogenic adipocytokine profile. We measured the effects of increasing obesity on the adipocytokine profile. We hypothesize that increasing degrees of obesity are associated with a more atherogenic profile.

Methods and Results We evaluated 23 overweight or obese patients with type 2 diabetes. Labs were drawn at baseline and following a standard test meal. The data were analyzed using Student's paired t-tests, and ANOVA. Subjects were grouped by BMI into quartiles. Subjects in the highest BMI quartile had significantly higher PAI-1 and lower adiponection concentrations compared to subjects in the lowest BMI quartile. There was a trend of increased hsCRP and fibrinogen with increasing BMI quartiles.

 

Additionally, PAI-1 was elevated during the postprandial period in the highest BMI quartile compared to all other quartiles.

Conclusion Increasing quartiles of obesity lead to a more atherogenic, adipocytokine profile. Additionally, increasing adiposity blunts the normal diurnal decrease in PAI-1. These data suggest that atherogenic risk may increase in parallel to increases in adiposity.

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