Autoimmune thyroid disease is common in systemic lupus erythematosus (SLE). About 20% of SLE patients have secondary Sjšgren's syndrome. We undertook this study to determine whether autoimmune thyroid disease is associated with secondary Sjšgren's syndrome in SLE. Families with more than one SLE patient were identified. All patients met the revised classification criteria, while SLE-unaffected relatives were confirmed not to satisfy these criteria. Diagnosis of autoimmune thyroid disease and Sjšgren's syndrome was made on the basis of medical records review, interview, and questionnaire in the SLE patients and by questionnaire in the SLE-unaffected subjects. Of a total of 1138 SLE patients, 169 had Sjšgren's syndrome. Fifty of these 169 (29.6%) also had autoimmune thyroid disease. Of the 939 SLE patients without Sjšgren's syndrome, 119 (12.7%) had autoimmune thyroid disease (Π2 = 20.1, p < .000009). There was no association of hypertension with secondary Sjšgren's syndrome (42% versus 47%). Among 2291 SLE-unaffected relatives, 44 had primary Sjšgren's syndrome and 16 (36.3%) of these also had autoimmune thyroid disease. 265 of 2247 (11.8%) had autoimmune thyroid disease but no Sjšgren's syndrome (Π2 = 24.2, p < .000009). Autoimmune thyroid disease is found in excess among SLE patients with secondary Sjšgren's syndrome as well as among their SLE-unaffected relatives with primary Sjšgren's syndrome.
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