Background The data on long-term effect of either metformin (MET) or caloric restriction in obese, premenopausal women with impaired glucose tolerance (IGT), with or without PCOS, are sparse.
Research Design and Methods We studied the effect of MET or lifestyle modification (LSM) in 348 premenopausal women 25/45 yrs old with IGT and no history of PCOS on proinsulin and HOMA-IR and androgenic profile consisting of total (TT), free (cFT) and bioavailable testosterone (bioT), DHEA, and androstenedione (A). We used one-way ANOVA to evaluate differences among treatment groups.
Results As shown in Table 1, averages for HOMA-IR and proinsulin decreased significantly by both MET and LSM. The androgenic profile when compared to placebo is not significantly changed in either arm.
Conclusion One-year treatment with MET or LSM in a DPP subgroup of obese premenopausal eumenorrheic women significantly changed glycemic indices with a greater effect by LSM. These interventions did not reduce gonadal androgens despite improvement in insulin sensitivity.