Introduction We have previously reported that a multicomponent model of autonomic and enteric factors can help predict gastric emptying in diabetes mellitus.
Patients 87 patients (38 males, 49 females; mean age 39 6 10 years) with diabetes mellitus presenting with signs and symptoms of gastroparesis.
Methods Autonomic tests included adrenergic tests by VC (vasoconstriction to cold) and PAR (postural ratio), cholinergic AFT was measured by ECG R to R interval (RRI). Enteric measure (EGG) was measured by cutaneous electrogastrogram. The data were compared to results of standardized solid gastric emptying reported as T50.
Results Patients were distributed in 5 groups based on gastric emptying time (GET): 28% very delayed, 15% delayed, 22% normal, 17% rapid, and 18% very rapid (Table 1). There were statistically significant differences among the 5 group means for VC and RRI but not for EGG and PAR (Table 2).
Conclusions A multicomponent model demonstrates specific autonomic and enteric differences in subgroups of diabetic gastroparesis. Therapies for diabetic gastroparesis, including drugs and devices, may need to take into account these physiologic differences when looking at therapeutic outcomes.
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