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405 PLASMA LEVELS OF C-REACTIVE PROTEIN IN OVERWEIGHT CHILDREN AND ADOLESCENTS WITH CARDIAC-RELATED FAMILIAL RISK FACTORS.
  1. W. N. Evans,
  2. G. A. Mayman,
  3. R. J. Acherman,
  4. K. A. Cass,
  5. K. T. Kip,
  6. A. Rothman,
  7. C. F. Luna,
  8. A. Gustafson,
  9. A. Lowe,
  10. L. Coviello,
  11. H. Restrepo
  1. Children's Heart Center, University of Nevada, School of Medicine, Las Vegas, NV

Abstract

Background Obesity has been associated with elevated C-reactive protein and increased cardiovascular risk. Genetic predisposition to atherosclerosis constitutes important risk for developing coronary artery disease (CAD).

Objectives To assess the relationship of some cardiac-related familial risk factors (FRF) with the plasma level of highly sensitive C-reactive protein (hs-CRP) in a group of overweight children and adolescents.

Methods This study included 101 children and adolescents with body mass index (BMI) ≥ 95th percentile, whose parents answered a questionnaire to address the familial history of diabetes, hypercholesterolemia, hypertension, heart attack, and congenital and/or acquired cardiac diseases. All children participated in a 12-week medically supervised risk factor reduction program. Fasting blood samples were drawn for determination of hs-CRP during the first visit.

Results There were 54 males and 47 females, mean age: 11.3 years (range: 5-17), mean BMI Z-score: 2.37 ± 0.32, Hispanic: 50%, Caucasian: 30%, African American: 17%, other races: 3%. There were 36 patients with 1 or none FRF and 65 with 2 or more FRF.

Conclusion In this group of overweight children and adolescents the presence of 2 or more familial cardiac-related risk factor was significantly associated with elevated plasma levels of hs-CRP. Elevation of hs-CRP in obese children and adolescents may help identify those individuals at high risk to develop CAD later in life.

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