In Chile, documented pediatric hantavirus infections are more numerous and severe (by 2004, 12.4% of total Andes virus infections) than in the United States (by 3/2002, 4.5% were pediatric). Acute disease severity of pediatric Chilean infections is similar to adults. This project aims to determine whether the degree of the humoral response during the acute phase determines the severity of the illness. Strip blot analysis was performed on pediatric and adult sera obtained from Chilean patients. Nine Chilean pediatric acute samples (≤ 15 years old) and nine adult acute samples (16-68 years old) are included. One acute pediatric sample was mild (11%), and eight pediatric acute samples were severe (89%). Three adult acute samples were mild (33%), and 6 adult acute samples were severe (67%). Nine adult convalescent patients (25-69 years old) and three pediatric convalescent sera (12-14 years old) are included. 100% of the three convalescent pediatric patients were severe, and three of the adult convalescent samples were mild (33%), with six of the adult convalescent samples being severe (67%). Preliminary results showed that in acute Chilean infections, adults had higher IgA titers than children, irrespective of disease severity. In mild infections, adults had lower IgM titers than children, with IgG titers remaining equivalent. In severe infections, IgM levels remained equivalent between adults and children, with adults having slightly higher IgG titers. In Chilean adults, patients with severe infections had higher IgM, lower IgG, and equivalent IgA titers compared to mild infections. Additionally, among convalescent patients, severe patients had higher IgM and IgG titers than their mild cohort group.
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