Purpose The purpose of this study is to investigate the correlation, if any, between the incidence of hemangiomas and the incidence of twinning in families of hemangioma patients. In addition, we would like to investigate at which order of family relation there is an increased incidence of twinning, if any.
Methods A series of patients who received surgical treatment for hemangioma by Dr. John Reinisch at Children's Hospital Los Angeles (CHLA) between 2003-2005 were identified. These patients were contacted by the investigators and asked questions regarding the incidence of twinning in their families and where in the family tree the twins occurred. Consequently, the patient was asked to provide a control family to answer the same questions regarding the incidence of twinning in their family and where in the family tree twinning occurred. The degree of family tree was calculated. The relative rates of incidence of twinning in the hemangioma patient population and the control group were calculated and compared.
Results A total of 164 hemangioma excisions on 154 patients were performed between 2003-2005 by Dr. John Reinisch at CHLA. Of these, 87 patients were successfully contacted and of these, 86 agreed to participate in the survey. The hemangioma population has a 61% (52/86) occurrence of twinning in their families. Of these, 23% (12/52) of patients were twins, 2% (1/52) occurred at the first order, 15% (8/52) at the second order, 19% (10/52) at the third order, 17% (9/52) at the fourth order, and 25% (13/52) at a higher order of family relation. A total of 42 of control subjects were identified. Twelve control subjects were contacted, who all agreed to participate in the study. The control population has a 58% (7/12) occurrence of twins in their families. Of these, 25% (3/12) of the control subjects were twins, no twins occurred in the first order, 8% (1/12) at the second order, no twins at the third order, 17% (2/12) at the fourth order, and 8% (1/12) at higher order of family relation. Further investigation is pending.
Conclusion Based on preliminary results, there is an increase in the incidence of twinning in families of hemangioma patients versus a control group, although it is not statistically significant. Additionally, there is an increase of twinning in the first, second, and third order family relation in the hemangioma patient population. Further investigation is pending.
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