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Innate Immune Response to Adenovirus
  1. Shoab A. Nazir,
  2. Jordan P. Metcalf
  1. From the Division of Pulmonary and Critical Care Medicine (S.A.N.), Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, and the Pulmonary and Critical Care Division (J.P.M.), Department of Medicine, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK. Dr. Metcalf is supported by an American Lung Association of Oklahoma Affiliate Grant, a grant from the Oklahoma Center for the Advancement of Science and Technology, and an American Heart Association Research Grant-in Aid.
  1. Address correspondence to: Dr. Jordan P. Metcalf, Oklahoma University Health Sciences Center, 800 N. Research Parkway, Room 425, Oklahoma City, OK 73104; e-mail: jordan-metcalf{at} .


ABSTRACT Adenovirus is a common infectious pathogen in both children and adults. It is a significant cause of morbidity in immunocompetent people living in crowded living conditions and of mortality in immunocompromised hosts. It has more recently become a popular vehicle for gene therapy applications. The host response to wild-type infection and gene therapy vector exposure involves both the innate and adaptive immune systems. The initial innate immune response is associated with the severe acute manifestations of adenovirus infection and also plays a significant role in acute toxicity owing to adenovirus vector exposure. This review discusses the innate immune response primarily during wild-type adenovirus infection because this serves as the basis for understanding the response during both natural infection and exposure to adenovirus vectors.

Key Words
  • adenovirus
  • innate immunity
  • cytokines

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